Estradiol and dehydroepiandrosterone potentiate levodopa-induced locomotor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys.
Identifieur interne : 002D83 ( Main/Exploration ); précédent : 002D82; suivant : 002D84Estradiol and dehydroepiandrosterone potentiate levodopa-induced locomotor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys.
Auteurs : Nancy Bélanger [Canada] ; Laurent Grégoire ; Paul Bédard ; Thérèse Di PaoloSource :
- Endocrine [ 1355-008X ] ; 2003.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Dehydroepiandrosterone (pharmacology), Dopamine Agents (pharmacology), Dose-Response Relationship, Drug, Drug Synergism, Estradiol (pharmacology), Female, Functional Laterality (physiology), Levodopa (pharmacology), Macaca fascicularis, Motor Activity (drug effects), Ovariectomy, Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (psychology).
- MESH :
- chemical , pharmacology : Dehydroepiandrosterone, Dopamine Agents, Estradiol, Levodopa.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- chemically induced : Parkinson Disease, Secondary.
- drug effects : Motor Activity.
- physiology : Functional Laterality.
- psychology : Parkinson Disease, Secondary.
- Animals, Dose-Response Relationship, Drug, Drug Synergism, Female, Macaca fascicularis, Ovariectomy.
Abstract
Six monkeys were rendered hemiparkinsonian with a unilateral injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. These monkeys displayed ipsilateral circling under basal conditions, and after dopaminergic stimulation with levodopa they decreased their ipsilateral circling and started turning to the contralateral side of their lesion. The effect of 17beta-estradiol and dehydroepiandrosterone (DHEA) was investigated in these animals. 17beta-Estradiol (0.1 mg/kg) added to a threshold dose of levodopa significantly potentiated contralateral circling (mean/30 min) compared to saline or threshold levodopa treatment whereas the duration of circling remained unchanged. DHEA (1-15 mg/kg) alone induced contralateral circling, compared to saline treatment, for 90 min. In addition, DHEA (1-15 mg/kg) potentiated the contralateral circling (mean/30 min) induced by a threshold dose of levodopa and did not change the duration of levodopa circling. A maximal response was observed with 1 or 5 mg/kg of DHEA combined with levodopa depending on the monkey. No correlation was found between the dose for the maximal DHEA response and baseline circling or threshold dose of levodopa. These results suggest that 17beta-estradiol or DHEA is able to potentiate locomotor activity of hemiparkinsonian monkeys. The DHEA doses investigated are similar to those presently used in humans. DHEA may be an alternative to 17beta-estradiol to modulate dopaminergic activity.
PubMed: 12777709
Affiliations:
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Le document en format XML
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last="Bédard">Paul Bédard</name></author><author><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12777709</idno><idno type="pmid">12777709</idno><idno type="wicri:Area/PubMed/Corpus">001432</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001432</idno><idno type="wicri:Area/PubMed/Curation">001432</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001432</idno><idno type="wicri:Area/PubMed/Checkpoint">001432</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001432</idno><idno type="wicri:Area/Ncbi/Merge">000306</idno><idno type="wicri:Area/Ncbi/Curation">000306</idno><idno type="wicri:Area/Ncbi/Checkpoint">000306</idno><idno type="wicri:doubleKey">1355-008X:2003:Belanger N:estradiol:and:dehydroepiandrosterone</idno><idno type="wicri:Area/Main/Merge">003173</idno><idno type="wicri:Area/Main/Curation">002D83</idno><idno type="wicri:Area/Main/Exploration">002D83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Estradiol and dehydroepiandrosterone potentiate levodopa-induced locomotor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys.</title><author><name sortKey="Belanger, Nancy" sort="Belanger, Nancy" uniqKey="Belanger N" first="Nancy" last="Bélanger">Nancy Bélanger</name><affiliation wicri:level="1"><nlm:affiliation>Molecular Endocrinology and Oncology Research Center, Laval University Medical Center (CHUL), Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Molecular Endocrinology and Oncology Research Center, Laval University Medical Center (CHUL), Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Gregoire, Laurent" sort="Gregoire, Laurent" uniqKey="Gregoire L" first="Laurent" last="Grégoire">Laurent Grégoire</name></author><author><name sortKey="Bedard, Paul" sort="Bedard, Paul" uniqKey="Bedard P" first="Paul" last="Bédard">Paul Bédard</name></author><author><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name></author></analytic><series><title level="j">Endocrine</title><idno type="ISSN">1355-008X</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Animals</term><term>Dehydroepiandrosterone (pharmacology)</term><term>Dopamine Agents (pharmacology)</term><term>Dose-Response Relationship, Drug</term><term>Drug Synergism</term><term>Estradiol (pharmacology)</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Levodopa (pharmacology)</term><term>Macaca fascicularis</term><term>Motor Activity (drug effects)</term><term>Ovariectomy</term><term>Parkinson Disease, Secondary (chemically induced)</term><term>Parkinson Disease, Secondary (psychology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dehydroepiandrosterone</term><term>Dopamine Agents</term><term>Estradiol</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Drug Synergism</term><term>Female</term><term>Macaca fascicularis</term><term>Ovariectomy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Six monkeys were rendered hemiparkinsonian with a unilateral injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. These monkeys displayed ipsilateral circling under basal conditions, and after dopaminergic stimulation with levodopa they decreased their ipsilateral circling and started turning to the contralateral side of their lesion. The effect of 17beta-estradiol and dehydroepiandrosterone (DHEA) was investigated in these animals. 17beta-Estradiol (0.1 mg/kg) added to a threshold dose of levodopa significantly potentiated contralateral circling (mean/30 min) compared to saline or threshold levodopa treatment whereas the duration of circling remained unchanged. DHEA (1-15 mg/kg) alone induced contralateral circling, compared to saline treatment, for 90 min. In addition, DHEA (1-15 mg/kg) potentiated the contralateral circling (mean/30 min) induced by a threshold dose of levodopa and did not change the duration of levodopa circling. A maximal response was observed with 1 or 5 mg/kg of DHEA combined with levodopa depending on the monkey. No correlation was found between the dose for the maximal DHEA response and baseline circling or threshold dose of levodopa. These results suggest that 17beta-estradiol or DHEA is able to potentiate locomotor activity of hemiparkinsonian monkeys. The DHEA doses investigated are similar to those presently used in humans. DHEA may be an alternative to 17beta-estradiol to modulate dopaminergic activity.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Bedard, Paul" sort="Bedard, Paul" uniqKey="Bedard P" first="Paul" last="Bédard">Paul Bédard</name><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name><name sortKey="Gregoire, Laurent" sort="Gregoire, Laurent" uniqKey="Gregoire L" first="Laurent" last="Grégoire">Laurent Grégoire</name></noCountry><country name="Canada"><noRegion><name sortKey="Belanger, Nancy" sort="Belanger, Nancy" uniqKey="Belanger N" first="Nancy" last="Bélanger">Nancy Bélanger</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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